Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874974 | 0.90 | KDM4E (0.52) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2874975 | 0.90 | KDM4E (0.52) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2244516 | 0.90 | CYP2E1 (0.40) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2878974 | 0.90 | KDM4E (0.51) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL323707 | 0.89 | KDM4E (0.50) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2425688 | 0.89 | KDM4E (0.50) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2430637 | 0.89 | KDM4E (0.50) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2879122 | 0.89 | KDM4E (0.50) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL14030859 | 0.88 | KDM4E (0.46) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL2876904 | 0.88 | KDM4E (0.46) | KDM4EHTTATMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |