Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.61 |
| ▸ | MTOR | P42345 | 6/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.61 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.52 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430944 | 1.00 | PIK3CA (0.61) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL1428344 | 0.91 | PIK3CA (0.65) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL1430684 | 0.91 | PIK3CA (0.65) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL4322386 | 0.85 | PIK3CA (0.64) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL4283598 | 0.85 | PIK3CA (0.64) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL3227843 | 0.85 | PIK3CA (0.77) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL1429366 | 0.85 | PIK3CA (0.77) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL8077258 | 0.85 | PIK3CA (0.69) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL1429224 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3CGINPPL1ABCC2 | |
| SCHEMBL1430215 | 0.84 | PIK3CA (0.68) | PIK3CAMTORPIK3CGINPPL1ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300460-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2011-03-30 | — | — | EP | claimed |
| EP-2300460-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2011-03-30 | — | — | EP | disclosed |