Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 15/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14291904 | 0.93 | TRPV1 (0.60) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL14292206 | 0.92 | TRPV1 (0.69) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL307203 | 0.90 | TRPV1 (0.56) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL14292049 | 0.87 | TRPV1 (0.72) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL14291911 | 0.87 | TRPV1 (0.69) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL307417 | 0.84 | TRPV1 (0.58) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL14292205 | 0.82 | TRPV1 (0.47) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL307584 | 0.82 | TRPV1 (0.67) | TRPV1ENPP2GPR139MAPK1 | |
| SCHEMBL309312 | 0.80 | TRPV1 (0.56) | TRPV1ENPP2GPR139 | |
| SCHEMBL309311 | 0.80 | TRPV1 (0.56) | TRPV1ENPP2GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008018827-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | WO | disclosed |