Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581038 | 0.92 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1IRAK4TTKPRKCQ | |
| SCHEMBL4580224 | 0.78 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1IRAK4TTKPRKCQ | |
| SCHEMBL4581830 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1IRAK4TTKPRKCQ | |
| SCHEMBL4581868 | 0.71 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL3628058 | 0.71 | HSP90AB1 (0.65) | HSP90AA1HSP90AB1 | |
| SCHEMBL3628057 | 0.71 | HSP90AB1 (0.65) | HSP90AA1HSP90AB1 | |
| SCHEMBL421243 | 0.71 | HSP90AA1 (0.62) | HSP90AA1 | |
| SCHEMBL14177807 | 0.70 | MAPT (0.46) | ARKMT2A | |
| SCHEMBL4581082 | 0.70 | PRKCQ (0.40) | IRAK4PRKCQPRKCDTBK1JAK2 | |
| SCHEMBL4580776 | 0.69 | PRKCQ (0.43) | IRAK4PRKCQPRKCDJAK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |