SCHEMBL14293302

SCHEMBL14293302

COc1ccc2c(-n3c(S)nnc3-c3ccc(N=O)cc3O)cccc2c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.37
HSP90AB1 P08238 1/20 0.37
IDO1 P14902 2/20 0.34
IDH1 O75874 2/20 0.34
MAPT P10636 4/20 0.33
KDM4E B2RXH2 3/20 0.33
POLB P06746 1/20 0.33
GAA P10253 4/20 0.32
MTNR1B P49286 2/20 0.32
AURKA O14965 1/20 0.32
MET P08581 1/20 0.32
KDR P35968 1/20 0.32
TEK Q02763 1/20 0.32
AURKB Q96GD4 1/20 0.32
MTNR1A P48039 1/20 0.32
MGAM O43451 1/20 0.32
SI P14410 1/20 0.32
MGAM2 Q2M2H8 1/20 0.32
L3MBTL1 Q9Y468 3/20 0.32
MEN1 O00255 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8930317 0.87 GAA (0.42) HSP90AA1HSP90AB1IDH1MAPTKDM4E
SCHEMBL14286453 0.86 MEN1 (0.40) HSP90AA1HSP90AB1MAPTGAAMGAM
SCHEMBL930819 0.84 HSP90AA1 (0.50) HSP90AA1HSP90AB1IDO1IDH1MAPT
SCHEMBL977297 0.82 IDH1 (0.38) HSP90AA1HSP90AB1IDH1GAAMTNR1B
SCHEMBL930543 0.79 GAA (0.42) HSP90AA1HSP90AB1IDH1MAPTKDM4E
SCHEMBL931820 0.79 GAA (0.38) HSP90AA1HSP90AB1IDH1MAPTKDM4E
SCHEMBL8930321 0.77 HSP90AA1 (0.38) HSP90AA1HSP90AB1MAPTKDM4EPOLB
SCHEMBL8930333 0.77 HSP90AA1 (0.44) HSP90AA1HSP90AB1MAPTGAAMEN1
SCHEMBL930137 0.75 MAPT (0.41) HSP90AA1HSP90AB1MAPTKDM4EPOLB
SCHEMBL8930323 0.75 HSP90AA1 (0.47) HSP90AA1HSP90AB1MAPTKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008021364-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2008-02-21 WO disclosed