Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171014 | 1.00 | BACE1 (0.77) | BACE1 | |
| SCHEMBL1170699 | 0.95 | BACE1 (0.76) | BACE1 | |
| SCHEMBL1429566 | 0.95 | BACE1 (0.76) | BACE1 | |
| SCHEMBL1429788 | 0.95 | BACE1 (0.76) | BACE1 | |
| SCHEMBL1170407 | 0.95 | BACE1 (0.76) | BACE1 | |
| SCHEMBL1171011 | 0.92 | BACE1 (0.65) | BACE1 | |
| SCHEMBL1429884 | 0.91 | BACE1 (0.77) | BACE1 | |
| SCHEMBL1170840 | 0.91 | BACE1 (0.77) | BACE1 | |
| SCHEMBL1429553 | 0.89 | BACE1 (0.75) | BACE1 | |
| SCHEMBL1170526 | 0.89 | BACE1 (0.75) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300484-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Pfizer Inc. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009136350-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PFIZER INC. (US) | 2009-11-12 | — | — | WO | claimed |