SCHEMBL14299043

SCHEMBL14299043

Cc1sc(C)c(C(=O)NC(C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 20/20 1.00
PTGER2 P43116 7/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2348710 1.00 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL2355907 0.88 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL14299810 0.88 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL13655944 0.87 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL2353056 0.87 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL4090963 0.86 PTGER4 (0.98) PTGER4PTGER2
SCHEMBL2353345 0.79 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL14299811 0.79 PTGER4 (1.00) PTGER4PTGER2
SCHEMBL28486614 0.78 PTGER4 (0.64) PTGER4PTGER2
SCHEMBL13649260 0.78 PTGER4 (0.82) PTGER4PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008017164-A1 THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS MERCK FROSST CANADA LTD. (CA) 2008-02-14 WO disclosed