Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.58 |
| ▸ | RAF1 | P04049 | 11/20 | 0.58 |
| ▸ | CSF1R | P07333 | 6/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676997 | 0.92 | RAF1 (0.61) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677289 | 0.89 | BRAF (0.65) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL12094186 | 0.88 | RAF1 (0.59) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677970 | 0.87 | BRAF (0.65) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677373 | 0.86 | BRAF (0.57) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL12094184 | 0.85 | BRAF (0.57) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2677441 | 0.85 | BRAF (0.59) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676441 | 0.85 | RAF1 (0.64) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL2676836 | 0.85 | BRAF (0.56) | BRAFRAF1CSF1RPDGFRBKIT | |
| SCHEMBL14300358 | 0.85 | BRAF (0.56) | BRAFRAF1CSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045528-A1 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045528-A1 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | CSF1R, CSF3R, FLT3 | BRAF 217/4885RAF1 750/4885CSF1R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.