Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.54 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | ROS1 | P08922 | 2/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 16/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794475 | 0.91 | NTRK1 (0.54) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL10284254 | 0.91 | NTRK1 (0.56) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL10284420 | 0.91 | NTRK1 (0.53) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL12136547 | 0.90 | NTRK1 (0.53) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL794172 | 0.90 | NTRK1 (0.53) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL773129 | 0.89 | NTRK1 (0.57) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL12135816 | 0.89 | NTRK1 (0.59) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL767929 | 0.88 | NTRK1 (0.56) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL10284424 | 0.88 | NTRK1 (0.57) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL767930 | 0.88 | NTRK1 (0.56) | NTRK1ACVRL1RETROS1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |