Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 18/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768265 | 1.00 | IGF1R (0.45) | IGF1RCYP3A4ADRB2ADRB1ADRB3 | |
| SCHEMBL794748 | 0.92 | NTRK1 (0.48) | IGF1RCYP3A4 | |
| SCHEMBL12136296 | 0.89 | IGF1R (0.44) | IGF1RCYP3A4ADRB2ADRB1ADRB3 | |
| SCHEMBL767717 | 0.89 | IGF1R (0.44) | IGF1RCYP3A4ADRB2ADRB1ADRB3 | |
| SCHEMBL794947 | 0.88 | IGF1R (0.47) | IGF1RCYP3A4 | |
| SCHEMBL10284252 | 0.87 | IGF1R (0.44) | IGF1RCYP3A4INSRPTK2 | |
| SCHEMBL768415 | 0.86 | NTRK1 (0.42) | IGF1RCYP3A4ADRB2ADRB1ADRB3 | |
| SCHEMBL10283930 | 0.85 | NTRK1 (0.55) | IGF1RCYP3A4 | |
| SCHEMBL773622 | 0.85 | NTRK1 (0.55) | IGF1RCYP3A4 | |
| SCHEMBL10284417 | 0.85 | NTRK1 (0.47) | IGF1RCYP3A4INSRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |