Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170646 | 1.00 | BACE1 (0.77) | BACE1 | |
| SCHEMBL1170643 | 0.93 | BACE1 (0.66) | BACE1 | |
| SCHEMBL1170790 | 0.90 | BACE1 (0.67) | BACE1 | |
| SCHEMBL1170465 | 0.90 | BACE1 (0.65) | BACE1 | |
| SCHEMBL2555345 | 0.89 | BACE1 (0.61) | BACE1 | |
| SCHEMBL1170383 | 0.87 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1430105 | 0.87 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1171332 | 0.87 | BACE1 (0.76) | BACE1 | |
| SCHEMBL1170548 | 0.87 | BACE1 (0.78) | BACE1 | |
| SCHEMBL2555344 | 0.87 | BACE1 (0.58) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136350-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PFIZER INC. (US) | 2009-11-12 | — | — | WO | claimed |
| EP-2300484-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Pfizer Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009136350-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PFIZER INC. (US) | 2009-11-12 | — | — | WO | disclosed |