SCHEMBL1430454

SCHEMBL1430454

O=C1C=C(N2CCC(O)CC2)CN1Cc1c(-c2ccc(Cl)cc2)nc2ccccn12

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.52
▸ KCNK3 O14649 17/20 0.52
▸ KCNK9 Q9NPC2 17/20 0.52
▸ GAA P10253 1/20 0.51
▸ SLC2A1 P11166 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1430370 0.95 KDM4E (0.51) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL1430272 0.89 KDM4E (0.64) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL1430474 0.87 KDM4E (0.54) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL1430128 0.78 KDM4E (0.56) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL1430908 0.73 KDM4E (0.54) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL18952321 0.70 KCNK3 (0.93) KCNK3KCNK9
SCHEMBL1429927 0.70 KDM4E (0.64) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL2227900 0.70 KDM4E (0.67) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL1430403 0.70 KCNK3 (0.48) KDM4EKCNK3KCNK9GAASLC2A1
SCHEMBL22364213 0.69 KCNK3 (0.76) KDM4EKCNK3KCNK9GAASLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. 2013-10-31 — — US disclosed
US-8497278-B2 Imidazo[1,2-a]pyridine compounds SUNOVION PHARMACEUTICALS INC. (US) 2013-07-30 — — US disclosed
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. (US) 2011-07-07 — — US disclosed
EP-2300470-A2 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS GABA-A RECEPTOR MODULATORS Sepracor Inc. (US) 2011-03-30 — — EP disclosed
WO-2009143156-A2 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SEPRACOR INC. (US) 2009-11-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD KDM4E 3088/4885KCNK3 2486/4885KCNK9 3527/4885
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD KDM4E 3088/4885KCNK3 2486/4885KCNK9 3527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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