Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.67 |
| ▸ | GSK3A | P49840 | 12/20 | 0.67 |
| ▸ | CDK7 | P50613 | 5/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.67 |
| ▸ | IGF1R | P08069 | 5/20 | 0.67 |
| ▸ | LCK | P06239 | 4/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.67 |
| ▸ | JAK2 | O60674 | 4/20 | 0.67 |
| ▸ | BTK | Q06187 | 1/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 13/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | PAK4 | O96013 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | FYN | P06241 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634796 | 0.88 | GSK3B (0.61) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27615961 | 0.84 | GSK3B (0.62) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778813 | 0.84 | GSK3B (0.71) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27615934 | 0.83 | GSK3B (0.66) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27615973 | 0.82 | GSK3B (0.59) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27634819 | 0.82 | GSK3B (0.71) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777186 | 0.81 | GSK3B (0.65) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27615818 | 0.81 | GSK3B (0.65) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777116 | 0.80 | GSK3B (0.68) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778596 | 0.80 | GSK3B (1.00) | GSK3BGSK3ACDK7AURKBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014249-A2 | IMPROVED PREPARATIONS OF 2 -SUBSTITUTED PYRROLO [2, 3-B] PYRAZINE ( 4, 7 -DIAZAINDOLE ) COMPOUNDS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |