Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | TEK | Q02763 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 11/20 | 0.53 |
| ▸ | BLK | P51451 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14304882 | 0.86 | LCK (0.55) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL14304339 | 0.83 | BTK (0.57) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL2498334 | 0.81 | BTK (0.61) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL14303236 | 0.81 | BTK (0.73) | LCKMAPK14KDRBTKBLK | |
| SCHEMBL5997067 | 0.81 | SRC (0.55) | SRCABL1 | |
| SCHEMBL2495019 | 0.79 | LCK (0.70) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL2498488 | 0.79 | LCK (0.67) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL14304879 | 0.78 | LCK (0.51) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL14303235 | 0.77 | BTK (0.49) | LCKMAPK14KDRTEKSRC | |
| SCHEMBL12190169 | 0.76 | LCK (0.68) | LCKMAPK14KDRTEKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |