Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 16/20 | 0.46 |
| ▸ | CCND1 | P24385 | 16/20 | 0.46 |
| ▸ | CCND2 | P30279 | 13/20 | 0.46 |
| ▸ | CCND3 | P30281 | 13/20 | 0.46 |
| ▸ | WEE1 | P30291 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.45 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.43 |
| ▸ | PAK3 | O75914 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189156 | 0.92 | WEE1 (0.54) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL188946 | 0.91 | WEE1 (0.47) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL4225936 | 0.87 | CDK4 (0.47) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL189185 | 0.87 | WEE1 (0.46) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL4352016 | 0.85 | WEE1 (0.44) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL189897 | 0.83 | KDM4E (0.57) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL14300938 | 0.83 | PIK3CD (0.58) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL189076 | 0.81 | CDK4 (0.42) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL3338688 | 0.79 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL189768 | 0.78 | HSD17B10 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |