Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.31 |
| ▸ | WNT3A | P56704 | 3/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306979 | 0.83 | HTR1D (0.36) | HTR1DHTR2CCTNNB1WNT3ACACNA1H | |
| SCHEMBL4523484 | 0.76 | MAOB (0.40) | P2RX7 | |
| SCHEMBL14272028 | 0.76 | — | — | |
| SCHEMBL4526156 | 0.75 | SLC8A1 (0.35) | — | |
| SCHEMBL13861832 | 0.73 | HTR1D (0.40) | HTR1DHTR2CCTNNB1WNT3AAXL | |
| SCHEMBL5950949 | 0.72 | BDKRB1 (0.35) | — | |
| SCHEMBL5950945 | 0.72 | BDKRB1 (0.35) | — | |
| SCHEMBL4521150 | 0.72 | MAP3K14 (0.46) | P2RX7 | |
| SCHEMBL26696481 | 0.71 | HTR1D (0.38) | HTR1DHTR2CCTNNB1WNT3AAXL | |
| SCHEMBL12316788 | 0.70 | NPC1 (0.39) | HTR1DHTR2CCTNNB1WNT3ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878728-A2 | Derivatives of piperazine and higher homologues thereof for the treatment of inflammation-related disorders | Amgen Inc. (US) | 2008-01-16 | — | — | EP | disclosed |