Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 13/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.46 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431508 | 0.92 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1431026 | 0.85 | PIK3CB (0.76) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1430871 | 0.84 | PIK3CB (0.77) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1431275 | 0.84 | PIK3CB (0.78) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1431382 | 0.82 | PIK3CB (0.79) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1431750 | 0.81 | PIK3CB (0.72) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1431167 | 0.77 | PIK3CB (0.76) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1430389 | 0.76 | PIK3CB (0.62) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL4306313 | 0.76 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR | |
| SCHEMBL1430937 | 0.75 | PIK3CB (0.58) | PIK3CBPIK3CAPIK3CGPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300483-A1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | Wyeth LLC (US) | 2011-03-30 | — | — | EP | disclosed |
| US-20090304692-A1 | Phosphatidylinositol 3 (PI3); Mammalian Target of Rapamycin, mTOR; triazine compounds substituted with either morpholino or tetrahydropyranyl rings on the triazine ring; anticancer agents, atherosclerosis, bone disorders, psoriasis, BPH, pancreatitis, kidney disease | WYETH (US) | 2009-12-10 | — | — | US | disclosed |
| WO-2009143317-A1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | WYETH (US) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304692-A1 | Phosphatidylinositol 3 (PI3); Mammalian Target of Rapamycin, mTOR; triazine compounds substituted with either morpholino or tetrahydropyranyl rings on the triazine ring; anticancer agents, atherosclerosis, bone disorders, psoriasis, BPH, pancreatitis, kidney disease | MTOR, PIK3CA, PIK3R3 | PIK3CB 20/4885PIK3CA 2/4885PIK3CG 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.