Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13333277 | 0.93 | PDPK1 (0.61) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL13306397 | 0.92 | PDPK1 (0.62) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL13306405 | 0.89 | PDPK1 (0.64) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL4989827 | 0.81 | MAPT (0.50) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL14090925 | 0.81 | MAPT (0.51) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL13306410 | 0.79 | PDPK1 (1.00) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL15871894 | 0.78 | PDPK1 (0.67) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL13306400 | 0.76 | PDPK1 (0.63) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL19788434 | 0.75 | ATM (0.69) | PDPK1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL4430752 | 0.74 | C3AR1 (0.46) | PDPK1MAPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| EP-2038272-B1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |