Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11346204 | 0.89 | IGF1R (0.70) | IGF1RNTRK1 | |
| SCHEMBL11339865 | 0.83 | IGF1R (1.00) | IGF1R | |
| SCHEMBL5867716 | 0.80 | CCNA2 (0.73) | — | |
| SCHEMBL11341250 | 0.78 | IGF1R (1.00) | IGF1RNTRK1 | |
| SCHEMBL4151522 | 0.77 | IGF1R (0.77) | IGF1RNTRK1 | |
| SCHEMBL12438096 | 0.77 | IGF1R (1.00) | IGF1RNTRK1 | |
| SCHEMBL14050602 | 0.76 | IGF1R (0.83) | IGF1R | |
| SCHEMBL11342614 | 0.76 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4069157 | 0.76 | IGF1R (1.00) | IGF1RNTRK1 | |
| SCHEMBL4459019 | 0.76 | IGF1R (1.00) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |