Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.70 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12337586 | 1.00 | IGF1R (0.70) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL12337769 | 0.91 | IGF1R (0.72) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL13696264 | 0.91 | IGF1R (0.71) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL12338128 | 0.91 | IGF1R (0.71) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL13865570 | 0.91 | IGF1R (0.71) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL13865558 | 0.89 | IGF1R (0.69) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL12923420 | 0.89 | IGF1R (0.69) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL12337959 | 0.89 | IGF1R (0.69) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL14320142 | 0.85 | ACVR1 (0.61) | IGF1RACVR1CCNE2CCNE1CDK2 | |
| SCHEMBL12314365 | 0.85 | ACVR1 (0.61) | IGF1RACVR1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |