Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14320760 | 1.00 | GSK3B (0.43) | GSK3BGSK3AAURKABRD4PIN1 | |
| SCHEMBL17113650 | 0.88 | TACR3 (0.41) | GSK3BGSK3AAURKABRD4PIN1 | |
| SCHEMBL18118010 | 0.88 | TACR3 (0.41) | GSK3BGSK3AAURKABRD4PIN1 | |
| SCHEMBL14328843 | 0.87 | BRD4 (0.40) | GSK3BGSK3AAURKABRD4PIN1 | |
| SCHEMBL13570465 | 0.86 | MAPT (0.47) | GSK3BGSK3AAURKAPIN1MEN1 | |
| SCHEMBL14320842 | 0.86 | MAPT (0.47) | GSK3BGSK3AAURKAPIN1MEN1 | |
| SCHEMBL14321995 | 0.86 | MAPT (0.45) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL14321994 | 0.86 | MAPT (0.45) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL14332506 | 0.85 | GSK3B (0.38) | GSK3BGSK3AAURKABRD4PIN1 | |
| SCHEMBL14321336 | 0.85 | GSK3B (0.39) | GSK3BGSK3AAURKABRD4PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962619-B2 | Substituted imidazopyridinyl-aminopyridine compounds | ARQULE, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8815854-B2 | Substituted imidazopyridinyl compounds | ARQULE, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-2723741-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2014-04-30 | — | — | EP | disclosed |
| US-20140073635-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ARQULE, INC. | 2014-03-13 | — | — | US | disclosed |
| US-8609688-B2 | Substituted imidazopyridinyl-aminopyridine compounds | ARQULE, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012177844-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012177852-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS | ARQULE, INC (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20120329791-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ArQuele, Inc. (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120329793-A1 | Substituted Imidazopyridinyl Compounds | ARQULE, INC. (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329791-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | GSK3B 2174/4885GSK3A 2135/4885AURKA 79/4885 |
| US-20140073635-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | GSK3B 2174/4885GSK3A 2135/4885AURKA 79/4885 |
| US-20120329793-A1 | Substituted Imidazopyridinyl Compounds | MKI67, CDK4, TP53 | GSK3B 1649/4885GSK3A 1585/4885AURKA 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.