Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.56 |
| ▸ | FLT4 | P35916 | 4/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205103 | 0.88 | EGFR (0.59) | EGFRPTK2FLT4ALKMET | |
| SCHEMBL14331661 | 0.87 | ALK (0.58) | EGFRPTK2FLT4ALK | |
| SCHEMBL10206118 | 0.81 | EGFR (0.52) | EGFRPTK2FLT4ALKMET | |
| SCHEMBL10205879 | 0.80 | EGFR (0.51) | EGFRPTK2FLT4ALK | |
| SCHEMBL10205074 | 0.80 | PTK2 (0.55) | EGFRPTK2FLT4ALK | |
| SCHEMBL10206116 | 0.79 | EGFR (0.48) | EGFRPTK2FLT4ALK | |
| SCHEMBL10206597 | 0.78 | ALK (0.53) | EGFRPTK2FLT4ALK | |
| SCHEMBL26611783 | 0.78 | EGFR (0.74) | EGFRPTK2FLT4ALKMET | |
| SCHEMBL10206144 | 0.77 | EGFR (0.59) | EGFRPTK2FLT4ALKMET | |
| SCHEMBL10205524 | 0.77 | EGFR (0.58) | EGFRPTK2FLT4ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329771-A1 | BENZYLIC OXINDOLE PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329771-A1 | BENZYLIC OXINDOLE PYRIMIDINES | MKI67, CCNI, CCNB1 | EGFR 1397/4885PTK2 1524/4885FLT4 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.