Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 1.00 |
| ▸ | AXL | P30530 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 5/20 | 0.59 |
| ▸ | JAK3 | P52333 | 3/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ULK1 | O75385 | 1/20 | 0.57 |
| ▸ | PRKCB | P05771 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377447 | 0.92 | JAK2 (0.85) | JAK2AXLJAK1JAK3 | |
| SCHEMBL14331978 | 0.89 | JAK2 (1.00) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14575027 | 0.88 | JAK2 (0.87) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14376752 | 0.87 | JAK2 (0.79) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL21799075 | 0.87 | JAK2 (0.79) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14332136 | 0.86 | JAK2 (1.00) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14376755 | 0.86 | JAK2 (1.00) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14331862 | 0.86 | JAK2 (1.00) | JAK2AXLJAK1JAK3CIT | |
| SCHEMBL14376758 | 0.85 | JAK2 (1.00) | JAK2AXLJAK1 | |
| SCHEMBL14377437 | 0.85 | JAK2 (0.79) | JAK2AXLJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721028-B1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORP (US) | 2015-11-04 | — | — | EP | claimed |
| US-20150225411-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2015-08-13 | — | — | US | claimed |
| US-9023840-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2015-05-05 | — | — | US | claimed |
| US-20140171409-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2014-06-19 | — | — | US | claimed |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-01-17 | — | — | US | claimed |
| US-11214573-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2022-01-04 | — | — | US | disclosed |
| US-11214573-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2022-01-04 | — | — | US | disclosed |
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2020-03-12 | — | — | US | disclosed |
| US-10513522-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2019-12-24 | — | — | US | disclosed |
| US-10513522-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2019-12-24 | — | — | US | disclosed |
| US-20170253598-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-20170253598-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-20140171409-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2014-06-19 | — | — | US | disclosed |
| EP-2721028-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8691807-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2014-04-08 | — | — | US | disclosed |
| US-8691807-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2014-04-08 | — | — | US | disclosed |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2012177606-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10513522-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-11214573-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-20140171409-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-20170253598-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
| US-20150225411-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.