Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620534 | 0.88 | TSHR (0.60) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL18394460 | 0.85 | CYP2C19 (0.61) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL25855066 | 0.85 | CYP2C19 (0.59) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL9977512 | 0.85 | CYP2C19 (0.59) | TSHRGRM2GRM3GRM4CYP2C19 | |
| Hydrochloric Acid SCHEMBL29031078 | 0.83 | CYP2C19 (0.58) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL11646566 | 0.83 | CYP2C19 (0.62) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL12246944 | 0.82 | TSHR (0.34) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL15557486 | 0.82 | KDM4E (0.41) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL31506997 | 0.82 | CYP2C19 (0.50) | TSHRGRM2GRM3GRM4CYP2C19 | |
| SCHEMBL3021254 | 0.81 | CYP2C19 (0.54) | TSHRGRM2GRM3GRM4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020128608-A1 | COMPOUND FOR USE IN A METHOD FOR TREATING SARCOIDOSIS-ASSOCIATED PULMONARY HYPERTENSION | ALTAVANT SCIENCES GMBH (CH) | 2020-06-25 | — | — | WO | claimed |
| EP-3041842-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | Karos Pharmaceuticals, Inc. (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2015035113-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-03-12 | — | — | WO | disclosed |
| EP-2300474-A1 | SPIRO (PIPERIDINE-4, 2 ' -PYRROLIDINE) -1- (3, 5- TRIFLUOROMETHYL PHENYL) METHYLCARBOXAMIDES AS NK1 TACHIKYNIN RECEPTOR ANTAGONISTS | Glaxo Wellcome Manufacturing Pte Ltd (SG) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009133135-A1 | SPIRO (PIPERIDINE-4, 2 ' -PYRROLIDINE) -1- (3, 5- TRIFLUOROMETHYL PHENYL) METHYLCARBOXAMIDES AS NK1 TACHIKYNIN RECEPTOR ANTAGONISTS | GLAXO WELLCOME MANUFACTURING PTE LTD (SG) | 2009-11-05 | — | — | WO | disclosed |