Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214792 | 1.00 | PIM1 (0.42) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL2215093 | 0.88 | PIK3CD (0.58) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL15387466 | 0.85 | PIM1 (0.41) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1771949 | 0.81 | IDO1 (0.39) | PIM1CLK2LRRK2 | |
| SCHEMBL2213348 | 0.80 | PIK3CD (0.56) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1960291 | 0.78 | PIK3CD (0.56) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1252933 | 0.77 | PIK3CD (0.68) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1120003 | 0.77 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1779380 | 0.77 | PIK3CD (0.53) | PIM1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1772516 | 0.76 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300437-A1 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES | Glaxo Group Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009147188-A1 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2009-12-10 | — | — | WO | disclosed |