Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.60 |
| ▸ | RAF1 | P04049 | 11/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746101 | 0.92 | BRAF (0.61) | BRAFRAF1MAPK8ERN1ABL1 | |
| SCHEMBL3814445 | 0.91 | BRAF (0.72) | BRAFRAF1MAPK8MAPK11MAPK14 | |
| SCHEMBL2745927 | 0.90 | BRAF (0.58) | BRAFRAF1MAPK8ERN1ABL1 | |
| SCHEMBL2746309 | 0.86 | BRAF (0.55) | BRAFRAF1MAPK8ERN1ABL1 | |
| SCHEMBL2746510 | 0.85 | BRAF (0.56) | BRAFRAF1 | |
| SCHEMBL2745964 | 0.84 | BRAF (0.56) | BRAFRAF1EGFR | |
| SCHEMBL2746513 | 0.84 | BRAF (0.56) | BRAFRAF1MAPK8ABL1FGFR1 | |
| SCHEMBL3808570 | 0.83 | BRAF (0.60) | BRAFRAF1MAPK8ERN1ABL1 | |
| SCHEMBL3813139 | 0.82 | BRAF (0.65) | BRAFRAF1MAPK8ERN1ABL1 | |
| SCHEMBL3814527 | 0.81 | BRAF (0.57) | BRAFRAF1MAPK8ERN1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281955-A1 | RAF inhibitors and their uses | ARQULE, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281955-A1 | RAF inhibitors and their uses | ARQULE, INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281955-A1 | RAF inhibitors and their uses | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885MAPK8 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.