Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 9/20 | 0.41 |
| ▸ | KLK1 | P06870 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 2/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432421 | 0.79 | KLKB1 (0.41) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL13416201 | 0.77 | KLKB1 (0.39) | KLKB1KLK1F7 | |
| SCHEMBL1431651 | 0.74 | MME (0.42) | KLKB1PSMB5PSMB1HTRA1MME | |
| SCHEMBL3148655 | 0.74 | KLKB1 (0.41) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL3149326 | 0.74 | KLKB1 (0.41) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL3148667 | 0.74 | KLKB1 (0.41) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL1433934 | 0.73 | KLKB1 (0.39) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL1433933 | 0.73 | KLKB1 (0.39) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL1433938 | 0.73 | KLKB1 (0.39) | KLKB1KLK1F7HTRA1 | |
| SCHEMBL1432218 | 0.73 | NAMPT (0.43) | KLKB1KLK1PSMB5MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |