⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331159 | 0.78 | — | — | |
| SCHEMBL2554291 | 0.75 | — | — | |
| SCHEMBL564530 | 0.72 | — | — | |
| SCHEMBL1956229 | 0.72 | — | — | |
| SCHEMBL11025 | 0.72 | — | — | |
| Water SCHEMBL15388360 | 0.70 | — | — | |
| SCHEMBL10152903 | 0.70 | — | — | |
| SCHEMBL3775653 | 0.70 | — | — | |
| SCHEMBL2538796 | 0.70 | — | — | |
| SCHEMBL21177233 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |
| US-8497380-B2 | Substituted acetophenones useful as PDE4 inhibitors | LEO PHARMA A/S (DK) | 2013-07-30 | — | — | US | disclosed |
| WO-2013082751-A1 | PHOSPHATE TRANSPORT INHIBITORS I | LEO PHARMA A/S (DK) | 2013-06-13 | — | — | WO | disclosed |
| WO-2013082756-A1 | PHOSPHATE TRANSPORT INHIBITORS II | LEO PHARMA A/S (DK) | 2013-06-13 | — | — | WO | disclosed |
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| US-20130012716-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | FELDING JAKOB (DK) | 2013-01-10 | — | — | US | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-20060084744-A1 | Silicone rubber composition comprising untreated aluminum hydroxide as filler | WACKER-CHEMIE GMBH (DE) | 2006-04-20 | — | — | US | disclosed |
| US-20060084745-A1 | Silicone rubber composition having improved storage stability | WACKER-CHEMIE GMBH (DE) | 2006-04-20 | — | — | US | disclosed |
| EP-1647579-A1 | Silicone rubber composition with prolonged potlife | Wacker Chemie AG (DE) | 2006-04-19 | — | — | EP | disclosed |
| EP-1647578-A1 | Silicone rubber composition comprising an aluminum hydroxide filler being not surface treated | Wacker Chemie AG (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-6359098-B1 | SHELF LIFE AS ONE-COMPONENT ADDITION-CURABLE ORGANOPOLYSILOXANES, AND EXTENDED POT LIFE FOR TWO-COMPONENT ADDITION-CURABLE ORGANOPOLYSILOXANES, WITHOUT COMPROMISING CROSSLINKING RATES OR LEVELS | WACKER-CHEMIE GMBH (DE) | 2002-03-19 | — | — | US | disclosed |
| EP-1077226-B1 | Curable Polysiloxane Compositions | WACKER CHEMIE GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| US-6252028-B1 | PLATINUM CATALYST | WACKER-CHEMIE GMBH (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-0994159-B1 | Curable organopolysiloxane composition | WACKER CHEMIE GMBH (DE) | 2001-04-04 | — | — | EP | disclosed |
| EP-1077226-A1 | Curable Polysiloxane Compositions | Wacker-Chemie GmbH (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0994159-A1 | Curable organopolysiloxane composition | Wacker-Chemie GmbH (DE) | 2000-04-19 | — | — | EP | disclosed |