SCHEMBL14345313

SCHEMBL14345313

C#Cc1ccc(NC(=O)c2cc(Cl)cc(OC)c2NC(=O)c2ccc(C(=N)N(C)C)cc2F)nc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 17/20 0.67
KCNH2 Q12809 3/20 0.59
F2 P00734 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14345252 0.93 F10 (0.58) F10KCNH2F2
SCHEMBL14345253 0.92 F10 (0.56) F10KCNH2F2
SCHEMBL14345322 0.92 F10 (0.56) F10KCNH2F2
SCHEMBL14345083 0.91 F10 (0.81) F10KCNH2F2
SCHEMBL14345231 0.91 F10 (0.67) F10KCNH2F2
SCHEMBL6711598 0.90 F10 (0.82) F10KCNH2F2
SCHEMBL14448949 0.89 F10 (0.61) F10KCNH2
SCHEMBL14345241 0.89 F10 (0.54) F10KCNH2F2
SCHEMBL10178777 0.88 F10 (0.70) F10KCNH2F2
SCHEMBL14345305 0.88 F10 (0.56) F10KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7312235-B2 Benzamide inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-12-25 US disclosed
US-7312235-B2 Benzamide inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-12-25 US disclosed