SCHEMBL14345323

SCHEMBL14345323

C=CS/C=C(\N)n1cc(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 19/20 0.51
CCND1 P24385 10/20 0.51
CCND3 P30281 6/20 0.51
CCND2 P30279 4/20 0.51
CDK6 Q00534 9/20 0.50
CCNA2 P20248 4/20 0.50
CDK2 P24941 4/20 0.50
CCNK O75909 2/20 0.50
CDK9 P50750 2/20 0.50
CDK1 P06493 3/20 0.47
CCNB1 P14635 3/20 0.47
FLT3 P36888 3/20 0.47
CCNA1 P78396 2/20 0.46
CHEK1 O14757 1/20 0.46
DAPK3 O43293 1/20 0.46
CCNT1 O60563 1/20 0.46
CCNT2 O60583 1/20 0.46
ROCK2 O75116 1/20 0.46
STK16 O75716 1/20 0.46
PDE5A O76074 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14345438 0.88 CDK4 (0.52) CDK4CCND1CCND3CCND2CDK6
SCHEMBL7712824 0.76 CDK4 (0.67) CDK4CCND1CCND3CCND2CDK6
SCHEMBL7706828 0.75 CDK4 (0.73) CDK4CCND1CCND3CCND2CDK6
SCHEMBL11977131 0.74 CDK4 (0.56) CDK4CCND1CCND3CCND2CDK6
SCHEMBL11977132 0.74 CDK4 (0.56) CDK4CCND1CCND3CCND2CDK6
SCHEMBL4191054 0.74 CDK6 (0.57) CDK4CCND1CCND3CCND2CDK6
SCHEMBL7706831 0.74 CDK4 (0.72) CDK4CCND1CCND3CCND2CDK6
SCHEMBL11977230 0.73 CDK4 (0.61) CDK4CCND1CCND3CCND2CDK6
SCHEMBL11977133 0.72 CDK4 (0.56) CDK4CCND1CCND3CCND2CDK6
SCHEMBL11977129 0.72 CDK4 (0.55) CDK4CCND1CCND3CCND2CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007140222-A2 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2007-12-06 WO disclosed