Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14345572 | 0.90 | HDAC6 (0.78) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8403304 | 0.88 | HDAC6 (0.82) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL14345697 | 0.87 | HDAC6 (0.89) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5356633 | 0.87 | HDAC6 (0.54) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8401966 | 0.87 | HDAC6 (0.79) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL14345610 | 0.87 | HDAC6 (0.79) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8403069 | 0.86 | HDAC6 (0.69) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8110103 | 0.86 | HDAC6 (0.81) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5351539 | 0.86 | MAPT (0.59) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5351536 | 0.86 | MAPT (0.59) | HDAC6HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143822-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | METHYLGENE INC. (CA) | 2007-12-21 | — | — | WO | disclosed |