Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.72 |
| ▸ | AKT2 | P31751 | 15/20 | 0.72 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14501119 | 0.85 | AKT1 (0.70) | AKT1AKT2AKT3 | |
| SCHEMBL5356510 | 0.85 | AKT1 (0.70) | AKT1AKT2AKT3 | |
| SCHEMBL3173016 | 0.84 | AKT1 (0.79) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL3167223 | 0.84 | AKT1 (0.79) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL5348455 | 0.84 | AKT1 (1.00) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL3980604 | 0.84 | AKT1 (0.78) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL2436521 | 0.84 | AKT1 (0.78) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL3978936 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL3983210 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL3979816 | 0.82 | AKT1 (0.75) | AKT1AKT2AKT3OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558586-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2011-03-30 | — | — | EP | claimed |
| US-7399764-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-07-15 | — | — | US | claimed |
| US-20050288294-A1 | Inhibitors of akt activity | MERCK SHARP & DOHME CORP. | 2005-12-29 | — | — | US | claimed |
| EP-1558586-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-1558586-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2011-03-30 | — | — | EP | disclosed |
| US-7399764-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-20050288294-A1 | Inhibitors of akt activity | MERCK SHARP & DOHME CORP. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288294-A1 | Inhibitors of akt activity | AKT2, AKT1, AKT3 | AKT1 2/4885AKT2 1/4885AKT3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.