Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.36 |
| ▸ | CALCA | P06881 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198170 | 1.00 | CALCRL (0.39) | CALCRLSCN9ARAMP1CALCA | |
| SCHEMBL2901939 | 0.83 | CALCRL (0.39) | CALCRLRAMP1CALCA | |
| SCHEMBL1197925 | 0.82 | CALCRL (0.54) | CALCRLSCN9ARAMP1CALCA | |
| SCHEMBL1198554 | 0.78 | CALCRL (0.39) | CALCRLRAMP1CALCA | |
| SCHEMBL1198278 | 0.78 | CALCRL (0.46) | CALCRL | |
| SCHEMBL13798878 | 0.77 | CALCRL (0.47) | CALCRL | |
| SCHEMBL4559699 | 0.76 | CALCRL (0.60) | CALCRLRAMP1CALCA | |
| SCHEMBL3066255 | 0.76 | CALCRL (0.60) | CALCRLRAMP1CALCA | |
| SCHEMBL13050655 | 0.76 | CALCRL (0.60) | CALCRLRAMP1CALCA | |
| SCHEMBL13036911 | 0.76 | CALCRL (0.60) | CALCRLRAMP1CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799672-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-01-02 | — | — | EP | disclosed |