Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 10/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CCNH | P51946 | 5/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.40 |
| ▸ | CDK9 | P50750 | 6/20 | 0.38 |
| ▸ | TTK | P33981 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 6/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346497 | 1.00 | CDK7 (0.41) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346522 | 0.94 | CDK2 (0.41) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346392 | 0.92 | CDK2 (0.42) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346508 | 0.92 | CDK7 (0.40) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346542 | 0.92 | CDK2 (0.42) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14364519 | 0.92 | CDK7 (0.40) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346162 | 0.87 | CDK2 (0.40) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14346165 | 0.87 | CDK2 (0.40) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14364520 | 0.87 | CDK2 (0.40) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL14364522 | 0.87 | CDK2 (0.41) | CDK7CDK2CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139732-A1 | PYRAZOLO [1, 5-A] PYRIMIDINES AS CDK INHIBITORS | SCHERING CORPORATION (US) | 2007-12-06 | — | — | WO | disclosed |