Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.44 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203763 | 0.90 | APP (0.67) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL3181774 | 0.88 | APP (0.71) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3198654 | 0.80 | APP (0.71) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3187032 | 0.79 | APP (0.70) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3181750 | 0.79 | APP (0.70) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3188005 | 0.77 | APP (1.00) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3192613 | 0.77 | APP (0.84) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL3188032 | 0.76 | APP (0.65) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL21566015 | 0.75 | APP (0.63) | APPNPC1RAB9ASMN1; SMN2TLR7 | |
| SCHEMBL13419363 | 0.74 | APP (0.84) | APPNPC1RAB9ASMN1; SMN2TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007149030-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |