Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29184862 | 0.89 | PDE4D (0.58) | PDE4DMAPTTDP1KDM4EPOLB | |
| SCHEMBL885177 | 0.88 | PDE4D (0.57) | PDE4DMAPTTDP1KDM4EPOLB | |
| SCHEMBL6129096 | 0.84 | POLB (0.65) | PDE4DMAPTTDP1KDM4EPOLB | |
| SCHEMBL102827 | 0.84 | MAPT (0.72) | PDE4DMAPTTDP1KDM4EMEN1 | |
| SCHEMBL7824239 | 0.84 | KDM4E (0.60) | MAPTTDP1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL1434488 | 0.83 | MAPT (0.50) | PDE4DMAPTTDP1KDM4EALDH1A1 | |
| Water SCHEMBL9749470 | 0.83 | MAPT (0.70) | PDE4DMAPTTDP1KDM4EMEN1 | |
| SCHEMBL27341170 | 0.83 | MAPT (0.70) | PDE4DMAPTTDP1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL5061862 | 0.83 | MAPT (0.70) | PDE4DMAPTTDP1KDM4EMEN1 | |
| Benzene SCHEMBL27688092 | 0.83 | MAPT (0.70) | PDE4DMAPTTDP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-B1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA AS (DK) | 2011-03-30 | — | — | EP | claimed |