Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.80 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885300 | 0.92 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434376 | 0.90 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885185 | 0.89 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885187 | 0.89 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885282 | 0.89 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434867 | 0.89 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885123 | 0.85 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885277 | 0.85 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885157 | 0.85 | PDE4D (0.92) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885307 | 0.84 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-B1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA AS (DK) | 2011-03-30 | — | — | EP | claimed |