Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 17/20 | 0.61 |
| ▸ | BRAF | P15056 | 16/20 | 0.61 |
| ▸ | FLT1 | P17948 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | YES1 | P07947 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5626946 | 0.88 | KIT (0.78) | KITBRAFFLT1KDRABL1 | |
| SCHEMBL4537062 | 0.88 | KDR (0.81) | KITBRAFFLT1KDRABL1 | |
| SCHEMBL14348637 | 0.80 | NOTUM (0.41) | KITBRAFFLT1KDRABL1 | |
| SCHEMBL5626575 | 0.78 | KIT (0.57) | KITBRAFFLT1KDRABL1 | |
| Motesanib SCHEMBL29354461 | 0.76 | KDR (1.00) | KITBRAFFLT1KDRABL1 | |
| Motesanib SCHEMBL187470 | 0.76 | KDR (1.00) | KITBRAFFLT1KDRABL1 | |
| Motesanib SCHEMBL445079 | 0.75 | KDR (0.98) | KITBRAFFLT1KDRABL1 | |
| SCHEMBL5626840 | 0.75 | CIT (0.62) | KITBRAFFLT1KDRABL1 | |
| SCHEMBL5627831 | 0.74 | MEN1 (0.55) | KITBRAFFLT1KDRABL1 | |
| Motesanib SCHEMBL29353301 | 0.74 | KDR (0.95) | KITBRAFFLT1KDRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307088-B2 | Substituted anthranilic amide derivatives and methods of use | AMGEN INC. (US) | 2007-12-11 | — | — | US | disclosed |
| US-7307088-B2 | Substituted anthranilic amide derivatives and methods of use | AMGEN INC. (US) | 2007-12-11 | — | — | US | disclosed |