Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885292 | 0.86 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434179 | 0.84 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434175 | 0.82 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885240 | 0.81 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885307 | 0.80 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885190 | 0.79 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885185 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885187 | 0.79 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434113 | 0.79 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434490 | 0.78 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-B1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA AS (DK) | 2011-03-30 | — | — | EP | claimed |