Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.57 |
| ▸ | RAF1 | P04049 | 7/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | PAK3 | O75914 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436443 | 0.93 | BRAF (0.67) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1434920 | 0.89 | BRAF (0.58) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1435177 | 0.82 | BRAF (0.69) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1435154 | 0.81 | BRAF (0.60) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1435355 | 0.80 | BRAF (0.84) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1435132 | 0.79 | BRAF (0.62) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL4440150 | 0.78 | BRAF (0.71) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL1435192 | 0.77 | BRAF (0.72) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL4341524 | 0.77 | BRAF (0.83) | BRAFCYP3A4RAF1LCKFYN | |
| SCHEMBL13559581 | 0.77 | BRAF (0.64) | BRAFCYP3A4RAF1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926722-B1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-09-28 | — | — | EP | claimed |
| EP-1924577-B1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | NOVARTIS AG (CH) | 2011-03-30 | — | — | EP | claimed |