SCHEMBL14355708

SCHEMBL14355708

O=C([C@@H](Cc1ccc(Cl)cc1)NC[C@H]1Cc2ccccc2CN1)N1CCN(c2ccccc2Cn2cncn2)CC1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MC4R P32245 20/20 0.53
MC5R P33032 2/20 0.41
MC3R P41968 2/20 0.41
MC1R Q01726 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5341100 1.00 MC4R (0.53) MC4RMC5RMC3RMC1R
SCHEMBL14356082 0.82 MC4R (0.51) MC4RMC5RMC3R
SCHEMBL14356076 0.82 MC4R (0.51) MC4RMC5RMC3R
SCHEMBL14355687 0.81 MC4R (0.53) MC4R
SCHEMBL14356078 0.80 MC4R (0.61) MC4RMC5RMC3RMC1R
SCHEMBL14356069 0.80 MC4R (0.51) MC4RMC5RMC3RMC1R
SCHEMBL14356081 0.79 MC4R (0.60) MC4RMC5RMC3RMC1R
SCHEMBL14356068 0.79 MC4R (0.53) MC4R
SCHEMBL13790223 0.79 MC4R (0.53) MC4R
Hydrochloric Acid SCHEMBL5338089 0.79 MC4R (0.50) MC4RMC5RMC3RMC1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291619-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2007-11-06 US disclosed
US-7291619-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2007-11-06 US disclosed