Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 14/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388970 | 0.96 | BDKRB1 (0.52) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| SCHEMBL5389050 | 0.92 | NISCH (0.54) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| Trifluoroacetic Acid SCHEMBL5384393 | 0.90 | BDKRB1 (0.50) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| SCHEMBL5384566 | 0.88 | BDKRB1 (0.56) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| SCHEMBL5381878 | 0.88 | BDKRB1 (0.56) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| SCHEMBL5393603 | 0.88 | BDKRB1 (0.59) | BDKRB1NISCHSMN1; SMN2LMNAHTT | |
| SCHEMBL5392295 | 0.88 | BDKRB1 (0.56) | BDKRB1NISCH | |
| SCHEMBL5383552 | 0.88 | BDKRB1 (0.56) | BDKRB1NISCHSMN1; SMN2MEN1POLB | |
| SCHEMBL5402622 | 0.88 | BDKRB1 (0.56) | BDKRB1NISCHSMN1; SMN2 | |
| SCHEMBL5383663 | 0.88 | BDKRB1 (0.60) | BDKRB1NISCHSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291642-B2 | Bradykinin-B1 antagonists, process for their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291642-B2 | Bradykinin-B1 antagonists, process for their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-06 | — | — | US | disclosed |