Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.86 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.85 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.60 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | PDE6A | P16499 | 1/20 | 0.57 |
| ▸ | PDE6G | P18545 | 1/20 | 0.57 |
| ▸ | PDE6B | P35913 | 1/20 | 0.57 |
| ▸ | PDE6C | P51160 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.57 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14362093 | 0.96 | PDE2A (0.86) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14362222 | 0.93 | PDE2A (1.00) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14362212 | 0.92 | PDE2A (1.00) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14362007 | 0.92 | PDE2A (1.00) | PDE2APDE11APDE10APDE6DPDE6A | |
| Hydrochloric Acid SCHEMBL17352452 | 0.91 | PDE2A (0.98) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14361983 | 0.89 | PDE2A (1.00) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14361881 | 0.88 | PDE2A (1.00) | PDE2APDE11APDE10APDE6DPDE6A | |
| SCHEMBL14361988 | 0.85 | PDE2A (0.84) | PDE2APDE11APDE10A | |
| SCHEMBL14362106 | 0.84 | PDE2A (0.86) | PDE2APDE11APDE10A | |
| SCHEMBL15745616 | 0.84 | PDE2A (0.85) | PDE2APDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604523-B2 | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-31 | — | — | US | claimed |
| EP-2723744-B1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-23 | — | — | EP | claimed |
| US-20140147386-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-29 | — | — | US | claimed |
| EP-2723744-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2014-04-30 | — | — | EP | claimed |
| WO-2013000924-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-03 | — | — | WO | claimed |
| US-10604523-B2 | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-31 | — | — | US | disclosed |
| EP-2723744-B1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-23 | — | — | EP | disclosed |
| US-20140147386-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-29 | — | — | US | disclosed |
| EP-2723744-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2014-04-30 | — | — | EP | disclosed |
| WO-2013000924-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140147386-A1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | PDE2A, PDE12, PDE5A | PDE2A 1/4885PDE11A 15/4885PDE10A 10/4885 |
| US-10604523-B2 | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives | PDE2A, PDE12, PDE5A | PDE2A 1/4885PDE11A 15/4885PDE10A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.