SCHEMBL14366331

SCHEMBL14366331

CO[C@@H](Cc1ccc(C#CCCCBr)cc1)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 11/20 0.67
PPARD Q03181 9/20 0.67
PPARG P37231 8/20 0.67
FFAR1 O14842 2/20 0.45
FFAR4 Q5NUL3 2/20 0.45
ITGB1 P05556 3/20 0.45
ITGA4 P13612 3/20 0.45
SRR Q9GZT4 3/20 0.41
PSAT1 Q9Y617 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5385447 0.88 PPARA (0.68) PPARAPPARDPPARGFFAR1FFAR4
SCHEMBL5377954 0.86 PPARA (0.52) PPARAPPARDPPARGFFAR1FFAR4
SCHEMBL22607958 0.84 PPARA (0.91) PPARAPPARDPPARGSRRPSAT1
SCHEMBL22607960 0.84 PPARA (0.91) PPARAPPARDPPARGSRRPSAT1
SCHEMBL5400562 0.80 PPARG (1.00) PPARAPPARDPPARGFFAR1
SCHEMBL5381961 0.80 PPARG (0.84) PPARAPPARDPPARG
SCHEMBL5381218 0.80 PPARG (1.00) PPARAPPARDPPARGFFAR1
SCHEMBL5380178 0.80 PPARG (0.84) PPARAPPARDPPARGSRRPSAT1
SCHEMBL5380189 0.80 PPARG (0.84) PPARAPPARDPPARGSRRPSAT1
SCHEMBL5381121 0.79 PPARG (0.94) PPARAPPARDPPARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors BROOKS DAWN A 2007-11-29 US disclosed
US-7192982-B2 Modulators of peroxisome proliferator activated receptors LIGAND PHARMACEUTICALS, INC. (US) 2007-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors PPARG, NCOA4, PPARA PPARA 3/4885PPARD 4/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.