SCHEMBL14366338

SCHEMBL14366338

CCOC(=O)[C@H](Cc1ccc(C#CCC(C)Oc2ccc(C(=O)c3ccccc3)cc2)cc1)OC

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPARG P37231 13/20 0.51
PPARA Q07869 13/20 0.51
PPARD Q03181 7/20 0.51
ACACB O00763 5/20 0.44
LMNA P02545 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5380839 0.85 PPARA (0.66) PPARGPPARAPPARDACACBLMNA
SCHEMBL6572905 0.81 PPARA (0.57) PPARGPPARAPPARDACACBLMNA
SCHEMBL5390421 0.80 PPARA (0.74) PPARGPPARAPPARDLMNAL3MBTL1
SCHEMBL6574275 0.78 PPARA (0.44) PPARGPPARAPPARDACACB
SCHEMBL14391963 0.78 PPARG (0.68) PPARGPPARAPPARDLMNAL3MBTL1
SCHEMBL5377922 0.76 PPARA (0.71) PPARGPPARAPPARDACACBL3MBTL1
SCHEMBL5382121 0.76 PPARA (0.71) PPARGPPARAPPARDACACBL3MBTL1
SCHEMBL5379589 0.75 PPARG (0.54) PPARGPPARAPPARDLMNAL3MBTL1
SCHEMBL14366349 0.75 PPARG (0.54) PPARGPPARAPPARDLMNAL3MBTL1
SCHEMBL5381926 0.75 PPARA (0.67) PPARGPPARAPPARDLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors BROOKS DAWN A 2007-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors PPARG, NCOA4, PPARA PPARG 1/4885PPARA 3/4885PPARD 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.