Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 15/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14452342 | 0.90 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ADORA2ATRAP1HSP90B1 | |
| SCHEMBL14366736 | 0.89 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ADORA2ATRAP1HSP90B1 | |
| SCHEMBL5606236 | 0.89 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14392851 | 0.89 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366739 | 0.87 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ADORA2ATRAP1HSP90B1 | |
| SCHEMBL5606565 | 0.85 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL4566497 | 0.85 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ADORA2ATRAP1HSP90B1 | |
| SCHEMBL14366737 | 0.85 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366733 | 0.85 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL5606020 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070253896-A1 | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070253896-A1 | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007092496-A2 | 7,9-DIHYDRO-PURIN-8-ONE AND RELATED ANALOGS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070253896-A1 | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors | HSP90B1, HSP90AB2P, HSP90AB1 | HSP90AA1 4/4885HSP90AB1 3/4885ADORA2A 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.