Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.52 |
| ▸ | KIT | P10721 | 17/20 | 0.52 |
| ▸ | FLT3 | P36888 | 16/20 | 0.52 |
| ▸ | CSF1R | P07333 | 7/20 | 0.48 |
| ▸ | FLT1 | P17948 | 7/20 | 0.48 |
| ▸ | FLT4 | P35916 | 7/20 | 0.48 |
| ▸ | LCK | P06239 | 6/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.48 |
| ▸ | PLK4 | O00444 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | INSR | P06213 | 3/20 | 0.48 |
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.48 |
| ▸ | STK3 | Q13188 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817289 | 0.94 | KDR (0.60) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2816792 | 0.93 | KDR (0.58) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2819284 | 0.93 | KDR (0.58) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2822262 | 0.92 | KDR (0.58) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2821071 | 0.92 | KDR (0.54) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2816524 | 0.90 | KDR (0.53) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2818309 | 0.89 | KDR (0.54) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2816983 | 0.89 | KDR (0.48) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2817303 | 0.89 | KIT (0.52) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2819473 | 0.89 | KDR (0.47) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144204-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-21 | — | — | WO | disclosed |