Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967316 | 0.81 | PSEN1 (0.47) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3904019 | 0.78 | ATM (0.58) | KMT2ALMNAMEN1RAB9ASIGMAR1 | |
| SCHEMBL24386385 | 0.78 | KMT2A (0.45) | ALDH1A1KMT2ALMNAMEN1RAB9A | |
| SCHEMBL8512 | 0.78 | AKR1B1 (0.48) | ALDH1A1KMT2ALMNAMEN1THRB | |
| Hydrochloric Acid SCHEMBL3297493 | 0.76 | AKR1B1 (0.46) | ALDH1A1KMT2ALMNAMEN1THRB | |
| SCHEMBL21981007 | 0.76 | MEN1 (0.50) | ALDH1A1KMT2AMEN1RAB9ASRC | |
| Phenaceturic Acid SCHEMBL14126285 | 0.75 | ATM (0.62) | ALDH1A1KMT2ALMNAMEN1RAB9A | |
| SCHEMBL5907106 | 0.75 | MEN1 (0.41) | KMT2AMEN1MAPK8SIGMAR1 | |
| SCHEMBL13329774 | 0.75 | KMT2A (0.53) | ALDH1A1KMT2ALMNAMEN1MAPK8 | |
| SCHEMBL964757 | 0.75 | MAPK8 (0.50) | KMT2AMEN1MAPK8SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |