Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903088 | 1.00 | PARP1 (0.56) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL3346129 | 1.00 | PARP1 (0.56) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL3344870 | 1.00 | PARP1 (0.56) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL3342685 | 0.82 | RET (0.48) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL3343396 | 0.82 | PARP1 (0.54) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL4923583 | 0.82 | PARP1 (0.54) | PARP1HPGDHSD17B10USP2THRB | |
| SCHEMBL13991180 | 0.82 | PARP1 (0.54) | PARP1HPGDHSD17B10USP2THRB | |
| Hydrochloric Acid SCHEMBL4907950 | 0.81 | PARP1 (0.53) | PARP1HPGDHSD17B10USP2THRB | |
| Hydrochloric Acid SCHEMBL4901800 | 0.81 | PARP1 (0.53) | PARP1HPGDHSD17B10USP2THRB | |
| Hydrochloric Acid SCHEMBL4110963 | 0.81 | PARP1 (0.53) | PARP1HPGDHSD17B10USP2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |