Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434218 | 0.85 | NAMPT (0.48) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL12431142 | 0.81 | DEGS1 (0.59) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL15706299 | 0.80 | DEGS1 (0.82) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL2235336 | 0.80 | HTT (0.57) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL6241013 | 0.78 | HDAC4 (0.71) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL21522275 | 0.78 | DEGS1 (1.00) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL20284448 | 0.78 | DEGS1 (1.00) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL12218306 | 0.77 | NPC1 (0.53) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL6366335 | 0.77 | HDAC4 (0.55) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL6366332 | 0.77 | HDAC4 (0.55) | DEGS1HDAC4ALDH1A1SMN1; SMN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |